Diverse functions of insulin-like 3 peptide

INSL3 (INSULIN-LIKE PEPTIDE 3) An Insulin-like Circulating Hormone

The Structural Determinants of Insulin-Like Peptide 3 Activity

Insulin-like peptide 3 (INSL3) is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor 8 (LGR8) which is now known as relaxin family peptide receptor 2 (RXFP2). Receptor activation by INSL3 involves bindi...

Study of the insulin-like peptide 3 in human platelets

The insulin-like 3 peptide (INSL3) is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine rich G-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in male development. [2] INSL3 mRNA has recently been verified in human platel...

Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4

The relaxin family peptides play a variety of biological functions by activating four G protein-coupled receptors, RXFP1-4. Among them, insulin-like peptide 5 (INSL5) and relaxin-3 share the highest sequence homology, but they have distinct receptor preference: INSL5 can activate RXFP4 only, while relaxin-3 can activate RXFP3, RXFP4, and RXFP1. Previous studies suggest that the A-chain is respo...

Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.

Insulin-like peptide 3 (INSL3), a member of the relaxin peptide family, is produced in testicular Leydig cells and ovarian thecal cells. Gene knock-out experiments have identified a key biological role in initiating testes descent during fetal development. Additionally, INSL3 has an important function in mediating male and female germ cell function. These actions are elicited via its recently i...